L1 retrotransposition has also been responsible for the insertion of over a million non- autonomous Alu retroposons and thousands of processed pseudogenes. The Human Genome Project estimated that over 500,000 L1 copies occupy 17% of human DNA, although it is believed that only about 100 of these remain potentially active in any individual. LINE1 retrotransposons are non-viral mobile DNA elements that duplicate themselves by a """"""""copy and paste"""""""" mechanism using an RNA intermediate. Furthermore, a corresponding increase in L1 ORF2 protein could account for increased levels of reverse transcriptase activity that have been detected in sera of ALS patients. We predict that the consequent increase in cellular levels of the L1-encoded ORF1p RNA-binding protein could increase its binding to proteins of significance for ALS or AD and promote their sequestration in stress granules and other cytoplasmic aggregates. We propose a novel hypothesis: rather than mutations at single gene locus, increased expression of ubiquitous LINE1 (L1) retrotransposons in the brains of ALS or AD patients, perhaps from many locations in the genome, contribute to the disease pathology. However, one common feature of many neurodegenerative diseases is protein aggregation, and it is widely thought that revealing the processes of cytoplasmic aggregate formation is key to better understanding the disease. A number of genes have been found, each explaining a minor percentage of familial cases and contributing little to our understanding of the pathogenesis of sporadic cases.
Much effort has been expended identifying susceptibility genes for amyotrophic lateral sclerosis (ALS) and Alzheimer's (AD) disease. John is a wise and wonderful member of the HOF Volunteer Family.Understanding the causes of neurodegenerative diseases with the aim of developing effective treatments is a significant medical challenge. The next time John stops by the Visitor’s Center, or you see him walking by with his wife take a moment to say hello. One of John’s great personal interests is flying… John is a licensed pilot and flies his plane out of Summit Airport, and furthermore, is still involved in the Civil Air Patrol! It is evident when you talk to him that next to his family his community is a major focus of his life. John truly cares about this community and the future of Odessa. He is trained as a HOF docent and receptionist and is always willing to fill in a pinch. in Middletown… just to name a few.Īs Chairman of the Historic Odessa Foundation Advisory Committee, John has been instrumental in the formation of the Foundation as a volunteer organization. John has been actively involved in many community organizations…holding offices in most of them the Appoquinimink School Board and the Church Connection Community U.M. He is a member and was past president of the Brain Injury Association of Delaware. He is active in Rotary International in the Middletown-Odessa Chapter, and was a member of the New Castle County Chamber of Commerce. He is a Mason, and since 1953 has served in various capacities, at all levels of membership, and in multiple chapters of that organization. John retired from PNC in 1992 as a Vice President. Twenty-seven of those years with the bank were spent in the Trust Department and nine years in Communications and Public Affairs. Army Field Medical Service Corps from 1953 to 1955, stationed at Brooke Army Medical Center in San Antonio, Texas.Īs a civilian, John was employed for the next thirty-six years by Equitable Security Trust Company, which later became Bank of Delaware, and finally became PNC. John was born in Vineland, New Jersey where he graduated from High School and then went on to Dickinson College in Carlisle, Pennsylvania. Their dedication to their community and their belief in support and good stewardship runs deep…their daughter Kelley also works as an HOF Volunteer, and their daughter-in-law, Rosemary, serves on the Historic Odessa Foundation Advisory Committee.
They have three children and 4 grandchildren. The young Goodier’s began their life together living in Bellevue Manor, eventually moving to Shallcross Lake in Middletown, and finally into Margie’s home town of Odessa in 1995. John’s mother was a Jefferis and it was one of her ancestors that married David Wilson of Cantwell’s Bridge in 1808. However, as John eventually came to find out, his connection to Odessa really began in the early nineteenth century. John is currently Chairman of the Historic Odessa Foundation Advisory Committee. John Goodier was first introduced to Odessa when he married Marjorie Loven in November of 1963. John claims that when he met Margie, he knew instantly he was going to marry her.
0 kommentar(er)
